Recently Lisa had her own DNA tested doing a comprehensive Genome report and Hormone report - testing offered by The DNA Company (www.thednacompany.com) and in this episode Dr Mansoor explains Lisa's genomic results and the implications for her health. 
 
The depth of the normal report means they only got to touch on a few of the gene results but the full comprehensive genomic report covers areas like:
 
  • Cardiovascular health
  • Mood and behaviour genes
  • Methylation genes 
  • Metabolism genes
  • Hormones
 
The insights garnered from these reports can help you avoid the possible major problems that could be coming your way if you aren't aware of them.
 
This information is by no means fatalistic or deterministic but rather to empower the individual to be aware of where certain risk factors lie and how you implement the diet, lifestyle and exercises changes required to avoid problems further down the track.
 
WHAT IS FUNCTIONAL GENOMICS?

Functional genomics is the study of how our genome interacts with the world around us. Because it's not just about where you come from. It's about where you can go.
Through a simple sample of your saliva, The Dna company are able to extract the information they need to provide you with a customized health report. To order a report contact support@lisatamati.com to arrange testing today.
 
We would like to thank our sponsors for this show:

For more information on Lisa Tamati's programs, books and documentaries please visit www.lisatamati.com
 
For Lisa's online run training coaching go to
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Lisa's third book has just been released. It's titled "Relentless - How A Mother And Daughter Defied The Odds"
 
Visit: https://relentlessbook.lisatam... for more Information
 
ABOUT THE BOOK:
When extreme endurance athlete, Lisa Tamati, was confronted with the hardest challenge of her life, she fought with everything she had. Her beloved mother, Isobel, had suffered a huge aneurysm and stroke and was left with massive brain damage; she was like a baby in a woman's body. The prognosis was dire. There was very little hope that she would ever have any quality of life again. But Lisa is a fighter and stubborn. She absolutely refused to accept the words of the medical fraternity and instead decided that she was going to get her mother back or die trying.
This book tells of the horrors, despair, hope, love, and incredible experiences and insights of that journey. It shares the difficulties of going against a medical system that has major problems and limitations. Amongst the darkest times were moments of great laughter and joy.
 
We are happy to announce that Pushing The Limits rated as one of the top 200 podcast shows globally for Health and fitness. 
**If you like this week's podcast, we would love you to give us a rating and review if you could. That really, really helps to show get more exposure on iTunes**
 
Transcript of the Podcast:
 
Speaker 1: (00:01)
Welcome to pushing the limits. The show that helps you reach your full potential with your host. Lisa tamati brought to you by Lisatamati.com.

Speaker 2: (00:13)
Everyone. Welcome back to pushing the limits. Um, I've had a very difficult time in the last month or two, uh, with the passing of my father. And I'm not going to go on to the details of that today. So I do apologize that a few of the podcasts episodes fell by the wayside, uh, during that time to your really difficult time. So thank you for your understanding. Uh, but we are back again and I will be sharing my father story in a later episode. Um, I am just, uh, gathering my resources to be able to talk about something that's very, very, very, it was a very difficult time, but, uh, today I have a very, very special treat for you. Again, um, this, this doctor has been on the podcast. This is the third time, and honestly, he's one of my greatest teachers. He's a mentor, he's an amazing role model.

Speaker 2: (01:04)
Um, and he is the world's leading number one scientist in the area of functional genomics. And I am very, very excited about the series of study, which I'm I'm studying now. Um, in today, dr. Mansoor Muhammad from the DNA company is the founder and CEO of, of the DNA company who do DNA testing is going to share with you some insights. I got my DNA done with his company, and we are going to go over my results today and share those publicly, um, and give you a little bit of an insight into what you can learn from doing your own DNA tests. So it's a really, really interesting now document. So it likes to go deeper into these topics. So we only managed to cover a few jeans today. Um, I hope to have him back again to cover some different areas, but it was a really deep insight.

Speaker 2: (02:00)
And I hope it gives you an insight into the importance of doing this sort of testing, having this understanding of what your genes are, and then how not for a fatalistic point of view that you were going to get anything, but to understand we, you have risk factors where you need to take some interventions from a lifestyle and, and, uh, you know, your nutrition, your lifestyle, all of that sort of thing, and how you can intervene if you have some problem areas. What you're here today is, uh, some of my problem areas I have quite a few. Um, so it was a really, really interesting conversation. I hope you do enjoy it. Um, before I hand over to dr. Mansoor, um, I would like to remind you, my book is now out and available. It's in book short stores throughout New Zealand. Relentless is the title, how a mother and daughter defied the odds.

Speaker 2: (02:52)
And it's a really powerful book that I hope is going to change many, many lives. And I would love you if you haven't already to go and grab a of that. So that's relentless. You can get it in bookstores in New Zealand, or if you are overseas, you can grab it on Amazon. You can grab it on Kendall. You can grab it on audio books or via my website at lisatamati.com, Which has all of the links to all the international suppliers of the book and all the New Zealand suppliers. So I really thank you for doing that and sharing the word. If you enjoy the book, please do share it with others. Let other people know that they can grab a copy too. The whole point of the book is really to open your eyes about taking responsibility for your own health about not accepting when people tell you there is no hope. Um, and as I said later on, I'm going to share my father's story, which was, um, tragic, but also quite, uh, an amazing journey. And yeah, there's still a lot more to be done on that one. So I won't go into it today right now, over to dr. Mansoor Mohammed of the DNA company. And I do hope you enjoy this episode.

Speaker 3: (04:01)
Hi, everyone,

Speaker 2: (04:02)
Back again with dr. Mansoor Mohammed, who is one of my favorites teachers and functional genomics scientists in the world, but he is the number one in the vote. And we've just had a very, very fascinating conversation, um, about, uh, uh, genes and elephants like medicine and functional medicine. But the topic for today's episode is going to, we going to do something a little bit different. Uh, we're going to go through my own gene report. So dr. Mansoor for those who don't know a dr. Mansoor, So he is from the DNA company. He is a functional genomic scientist who has been on this podcast already twice before. This is the first time in the history of pushing the limits that we've had someone on three times, and I honestly could have dr. Mansoor Every week, um, welcome to the show dr. Mansoor, Or it's an absolute privilege to have you met again in today.

Speaker 2: (04:55)
We're going to go over my report, um, and share with the world what it is that the DNA company does, what functional genomics is about, and then actually go over some of my genes and what they imply for my life and for my, uh, health moving forward and what I need to be aware of. So, dr. Mansoor welcome to the show. It's such an absolute on that Lisa for the audience out there. Please give me for throats is just a little bit tone the down patients pretty much on the hour, every hour, disclaiming, number one, describing, number two Lisa. Is there any bleed through of background noise that is coming through the microphone? No, we're all good because we'd all stay at home orders that are still in different degrees of implementation. We're having some work done at my home. We're still working from my home office and there's only so much I can do to keep up. It's not a problem. So the audience out there, you should obviously you're lisa's audience.

Speaker 4: (05:58)
You know, that she's a force. That is the world's been blessed with her. She does. So really it's just my honor, that she would even deem to ask me to come back. And what we're going to do is we're going to have some fun at the extensive Lisa today. You've obviously gotten to know her through listening to her amazing podcasts or life journey and seeing her as a perform performance lead person, and then the person behind that performer. But now you're going to see something. And what we're going to do today is at least for the time that we've given, find a few of the jewels that's behind behind the performer, I E Lisa's genomic makeup. And what we will do is we will deconstruct the date. Some of the data that comprises these says genomic makeup, look at how we grow interpreters in functional genomics. And I'll describe, and I will, I will define some of these things here shortly. Okay.

Speaker 2: (07:01)
That sounds brilliant. So just to give the listeners a bit of background, the DNA company based in Canada, run and founded by dr. Mansoor has a hormone reports and a whole genome report that looks at a set of the genes that are really, um, genes that we can do something about. Would that be a good way of putting it documents or cause we have 23,000 genes and our make up roughly.

Speaker 4: (07:31)
So first and foremost, what is the DNA company? We, we take our IP, we take our unique way of looking at the genome of the human being. And what is that unique way? The core of what we do differently leases simply this, the core is when you understand that a person's DNA DNA being the qualification system for genes, genes, being the instructions that, you know, take care of the multitude of functions that the cells need to perform to keep us thriving. That DNA is a language in enough itself. It really is. And so unfortunately thus far in genetics and this, so the audience has been Lisa hinted earlier of the lively conversation we were having prior to coming online, that allopathic medicine is in genetics, much like other parts of medicine. We take a very siloed approach to things. So in medics, what you'll tend to find is if you look at the vast majority of genetic reports or simply even the philosophy of genetics out there is here's the gene here's its job here is a variation in that gene.

Speaker 4: (08:39)
And then let's document what that might mean. And then there are a hundred others, a thousand others. And as Lisa's pointed out, there are 23,000 odd genes in the human genetic makeup. Now, if you were to do that, what you doing per the analogy of what I started with this would be like studying the vocabulary of a language. In other words, the language definitely one of the things that makes a person, an expert makes a person fluent in a language is the vocabulary. The more words you know, that will help you in understanding the language. Good. However, a language is much more than just vocabulary. A language is about grammar. It's about how sentences are structured. If you really want to be fluent in a language, you have to understand how to frame the discussion and how to frame the discussion. As in, how do we take genes in cascades and understand them?

Speaker 4: (09:37)
So the DNA company, what we do differently is we look at genetics through the lenses of functional cellular, biochemical, cascades, and pathways, because that's how the human body works. In other words, what you start with is you start with the human being. You start with the person in front of you. You look at their biologic principles, their processes, you can dive deep. When you go to the cellular level, you ask, what are the cascades, the biochemical cascades that are needed. Then you ask what are the genes that contribute to that, those cascades. Then you ask what are the variations in those genes by then, uh, the permutations and combinations of how those genes work together that might make that cascade more or less optimal. This is functionality only when you understand genes in the cohesive connective language based system. Can you really interpret genetics and intelligent?

Speaker 4: (10:43)
And what are we going to see here with Lisa today is I'm going to give you a few of these ju insights taking Lisa's genes individually, but show how they connect together to tell stories about Lisa behind the scenes cellular Lisa cellular Lisa Tamati, we're going to see how are things working in her? When are they optimal? When are they less optimal? When are they less optimal in particular nutritional environmental lifestyle decisions? So then intelligently, if we know that this is what is happening, we can say, here's how we can do to improve the outcome. That if left alone might not be as desirable as we want it to be, that's what we do differently. So succinctly put, so it's looking at pathways and hole. What is, it's not just taking one gene saying, well, this is some optimal. Therefore you have this, but it's looking at combinations of genes that are on different parts of the genome, even which I found fascinating. It's not just the methylation works and looked at the methylation, but

Speaker 2: (11:54)
It can affect the hormones. It can fix the other parts of it. So this is going to be really fascinating and I'm really baring my soul here. People were like, this is why genes, but I want to share this information because I want you to understand why understanding and knowing your genes will be powerful for a preventative approach to your health and looking after your health and your longevity. So a lot of people saying dr. Mansoor, just before we go in that genes. If I know my genes, that's fatalistic. If I've got the BRCA gene before I'm going to get breast cancer, and that is not the approach that you take or that I understand to be correct, it's not fatalistic.

Speaker 4: (12:35)
Absolutely it is not. So in fact, it is everything but being fatalistic. In fact, it is an understanding and we could go down, we can do a whole podcast on the BRCA gene. I spoke two years ago, um, at the cancer awareness, it's this, you know, it's an awareness fundraiser. It's the who's who in Canada that show up at this big event. And I was the speaker two years ago and I asked audience, I said, everyone in the audience, the size started my target. So everyone in the audience that is familiar with the BRCA two gene put their hands up. And everyone, as you might imagine at the breast cancer awareness, but I said, everyone in the audience put their hands up. And one year a woman who had happened to do the test with us and she put her arms up and I said, this represents the travesty of one subset of medicine, E individuals that are involved in the breast cancer world, both of the patients and the clinical level that all of you should know the BRCA about the BRCA gene. But one of you in an audience of almost 500 people should have heard of this 1B1. So it is not to be fatalistic. Lisa, not in the least. It is to be empowering it's to allow individuals to better appreciate here's my operating manual. And we're going to get into this now. And I would just say to your audience, you know, Lisa,

Speaker 2: (14:05)
Many times Even a truly,

Speaker 4: (14:06)
It was, you know, companies, obviously we have to do things. We have to stay relevant and we have to stay financed and so on and so forth. And so even I have times where I have to battle with people telling me, you know, the average consumer has a grade eight or grade seven, uh, ability to read. So, you know, we've got to dumb it down a bit. Okay? Here's my response to this, Lisa, and to all of your amazing audience members, I asked one question, mind you, the world has changed somewhat since covert. So this analogy might be slightly, but here's the point. The last time you planned for a beautiful vacation, a trip, or the last time you plan to replace that car and you're going to now buy a new car. How much time did you take researching that destination researching what currencies needed, the safety of the place you're going to the cultural norms,

Speaker 2: (15:06)
How much time effort.

Speaker 4: (15:10)
learning That thing, learning about a microwave for heaven sakes before you buying it, or the latest, greatest vacuum cleaner Do we take as individuals learning about ourselves, learning about how our bodies work. Exactly.

Speaker 2: (15:29)
It's because we have somehow been

Speaker 4: (15:32)
Either willfully or not brainwashed into thinking, well, you know, at the end of the day, if someone keeps telling you, you know, what the human body is too complex for you to ever understand, it don't even bother trial. Then at some point in time, you kind of go, well, I guess,

Speaker 2: (15:48)
Yep.

Speaker 4: (15:51)
I think that we've got to break Lisa, we've got to first and foremost, get rid of this outdated elitist perspective that the human body can only be understood if you've got a

Speaker 2: (16:06)
Yeah,

Speaker 4: (16:06)
I said, we're not all going to be neurologists, so we're not going to all be anesthesiologists or whatever.

Speaker 2: (16:12)
But if you appreciated how much

Speaker 4: (16:16)
Of yourself that you can better understand that you could actual lines that will make you feel empowered of taking health steps for you and your family members. Good God, we could dramatically improve the health of our health of our societies.

Speaker 2: (16:33)
Yes. And that's why I think the people that are listening,

Speaker 4: (16:37)
I'm probably probably preaching.

Speaker 2: (16:39)
Um, because you know, I don't have a medical background. And yet the story with my mom as people will know, um, the medical professionals were at the end of their abilities to help her. And we were told there was no coming back. Well, you know, four years later, as you can see, my mum is completely normal, lucky because I did not accept. And what I want people to take away from that story is to take ownership to within your ability, to be proactive and to not give up your control to any one person to anyone you don't have to just give up your control of your own health to your local doctor or to any one person at all, you know, do your own research by all means, go to your doctor, get the information and then go and do your research. That's all we're asking really. Uh, and the gene tests help us to understand on a level that is really, really fundamental. Um, some of these processes,

Speaker 4: (17:39)
Absolutely. So Lisa, here's what we're going to do. So, and for the audience, we're clearly not going to go through all of the amazing things, make up Lisa to be that amazing person. But like she said, she's bearing her soul. She's bearing her DNA. And what I'm going to do is I'm going to pick a few of the pathways, not just genes show you a as it applies to Lisa, but more ultimately the reason Lisa is doing this is to show you the listener, the equal of this are your genetic understanding what you've been meaning for you now, Lisa, I don't think we could have something more time appropriate as to the concerns if our current, you know, dealing with the COVID pandemic. And so here's something as a human being, the human body is challenged constantly, not just with the current virus, not just with the salt scrubs.

Speaker 4: (18:30)
We're constantly challenged with viruses and microbia, that are part of the world that we live in. But one of the most important bodily responses, obviously to a microbial infection is the anti microbial capacity of the human body. Now, when you think of the antimicrobial capacity of the human body, most of us to agree that we're relatively familiar with, you know, human body physiology, we think of antibiotics, isn't it? Yeah. Well actually, sorry. We think of antibodies, the immune systems antibodies. And of course, for me, treatments perspective, we think of antibiotics and slippers. Of course, we've got dr. Alexander Fleming given the, the mantle of discovering antibiotics, but that same Dr. Fleming before he discovered antibiotics had discovered something that he felt was even more remarkable because it was not patentable. And because he couldn't and the powers to be could not figure out how to commercialize it.

Speaker 4: (19:41)
It got lost in the wayside. What did he discover? He discovered something called anti microbial peptides, anti microbial, peptides, antimicrobial, peptides to date. There are. Now we now understand there are dozens of genes system, a small subset of the 20 plus thousand genes, but as a whole dozens, if not well, over a hundred genes in our operating manual, what do these genes do? They include these peptides, short sequences of amino acids. In other words, all proteins and these peptides have profound microbial properties. And they're distinct from your antibodies. They're distinct from the immunoglobulins, the IgGs IGS IGMs on GE. So lessons that are produced by your B cells are completely distinct from that. And actually these amps antimicrobial peptides, which we have again, dozens of our genes, making different antimicrobial peptides. Wow. On one of the first order defense mechanisms against microbial infections, including viruses, bacteria, and other microbiome.

Speaker 4: (21:12)
Okay. So we are exposed as human beings to microbial agents. One of the very first things our body has to do while it is making its B cell immunoglobulin response, is that it expresses these amp genes that act as a first line defense to microbial infections. Why is this potent? And what does it have to do with genetics? Well, it has to do with your vitamin D. So now we've introduced this by the way, audience, this is functional medicine, functional genomics, understanding the parts of the picture and putting it together. So now we switch gears from this critical part of your immune system to vitamin D many of us think of vitamin D is this micronutrient, right? Did you think of there's vitamin C and antioxidant? There's vitamin a there's like the vitamin BS and so on and so forth. And in that list of what we call the alphabet vitamins, we've got vitamin D nothing can be further from the truth.

Speaker 4: (22:17)
Wow. Is a hormone first. And what is the definition of hormone? Something that is produced in one part of the body that packs and signals the rest of the body. So it's just in one discrete place yet. It has ramifications throughout the bottle. Well, vitamin D is produced in the dermal layer, secondary to UV BS. Induction goes to the liver, it gets modified, it becomes activated, and then it impacts the body. How does vitamin D this one, if the audience walks away with just one thing from today, let them walk away with questioning themselves. How does vitamin D when you take that all, you know, important, cheap vitamin D supplement, or you go in the sun, how does vitamin D do what it does in the human body? Let's repeat this. Lisa vitamin D is a transcript, a gene transcriptional regulator. Wow. Do like literally is vitamin D involved in a building process within yourself, no vitamin D and tourism to ourselves by binding your receptor cells of our body.

Speaker 4: (23:39)
There are vitamin D receptors, the vitamin D from the bloodstream. Of course, that means that the vitamin D was there in the bloodstream in the first place, binds to the receptors in ourselves, into ourselves, and that vitamin D receptor complex and nuclei where our genes are housed. And what does it then do? It turns on and off genes and over a thousand genes. When you, when you're itself of bathe, it invites them in D the gene expression, signature, which genes are turned on, which genes are turned off changes. Now let's come back to those dozens of genes that encoded these anti microbial peptides. Guess what turns on those genes? Vitamin D D wow. Item indeed, when presence at optimal levels. And that's the point it has to be present at optimal levels is needed for your body's literally first, most important first line defense against like crew Bial, insults it's vitamin D D was needed so that your body can respond through the expression of these amps, to the infection. Okay. Fair enough. Wow.

Speaker 4: (25:10)
Absolutely way to tax the immune system as well in multiple different ways, but just so discretely as an a priority system that we don't talk about anymore, because unfortunately it could not be patented and benefited forgotten about. Now let's put these two things together. The obvious ramifications of these two systems coming together should be clear to the audience. Now let's talk genetics. Okay. So very, very quickly. Here's what happens with the story of vitamin D very quickly, you get exposed to the sunlight, the UVB, in this regard, we're somewhat like plants. It's an actual photosynthetic reaction. It stimulates an enzymatic reaction that produces this vitamin D precursor, that precursor is taken to the liver from the dermal cells. And in the deliver that precursor is activated and it is activated into the one 25 dihydroxy calciferol, which is your activated vitamin D three D three.

Speaker 4: (26:26)
Yeah, actually that's a common misconception. D3 is the precursor. The three is between the original precursor to produce them the dermal cells, but D3 is not 125. Dihydroxy what, uh, what we'd call the, the, the 25 hydroxy procepheral. And then the 125 dihydroxy procepheral is downstream modification of dethrone. No 1 gene sip to our one CYP of that massive important four 50 CYP, four 50 mega family of genes. What do the cytochrome P four 50 genes. It's this huge family sit to our 1's 1A2 1A1 3A4 and so on. And sort of, it's a mega family of genes. These genes and code enzymes, these enzymes are in essence responsible for your phase one metabolism so that the body needs to bio transform a into B. That's what the cytochrome P four 50 is do. They're massively involved in the metabolism of the medications that we take, which is where we will field of pharmacogenomics.

Speaker 4: (27:54)
For example, now, specifically to river one, CYP two are one. This is the member of the family that makes itself named G enzyme to our one enzyme. And what's the job of this enzyme will amongst other things, this enzyme exclusively activates and converts the vitamin D precursor into the 25 of them. One 25 dihydroxy calciferol okay. Now here is functional genomics at its best. Let's quickly complete the story. Then we get to Lisa's results. Often activated one 25 hydroxy calciferol we'll just call it from here on forth. Vitamin D okay. Once the vitamin D has made them deliver, it needs to get into the bloodstream. Cause of course, you don't want all your vitamin D just to deliver. It needs to get into the bloodstream. We circulated into the body. Why? Because we want to binding those receptors, entering ourselves and doing all of the wonderful things that we'll do from a gene gene expression perspective.

Speaker 4: (28:57)
Once it gets into ourselves, okay, well, we've run into a little snug they're biologically, because it turns out that vitamin D is fat soluble and the blood is water. How do you transport a fat soluble thing, any water based medium? Well, the body does the problem and the body has an ingenious way of figuring that out. The body produces this, this, this transporting Felix, this taxicab that will encapture the vitamin D that otherwise will be dissolvable in the blood to allow it to be to the sports. I mean, this is known as the VDB P vitamin D binding protein is the product of a gene in and of itself. There's a gene, the VDB P gene that makes the vitamin D binding protein. That is the taxicab of the vitamin D checkmark. Then the vitamin D being carried by the taxicab gets to the cells.

Speaker 4: (29:54)
It does not enter the cells just by diffusion. It enters the cells by binding to that receptor, that specific receptor, allowing it to be engulfed into the cell and going and doing the gene transcription job. Vitamin D receptor is the product of yet another gene, the function up gene. So here, we've got, we've got the CEP to our one gene that is activating and making the vitamin G we've got VDB P that will then take the vitamin D and transport it. We've got the VDR that then becomes the receptor to allow the vitamin D to be entered into the cell. This is functional genomics because here it goes. Many reports that elsewhere that would look at the situ are one gene. The gene is making vitamin D. Here is the gene determines if you have healthy levels of vitamin D only the first thing it turns out, you know, serendipitously Lisa and I, we didn't construct this.

Speaker 4: (31:02)
This is actually her results. Lisa has the optimal version of the CYP2R1G, meaning Lisa's gene that encodes the enzyme, that enzyme, that activates vitamin D. She has got a high efficiency version of that enzyme. So will we to do one of these superficial gene reports? We would say, Lisa's got genetic equivalent of that's what we would say, hold on, understand the story could not have been so premature. She does have the gene that activates vitamin D kinetically catalytically optimally. With now let's finish this story you see, because that vitamin D isn't going anywhere, anytime, fast in the bloodstream, unless it can be picked up by that taxi cab. Wow. This is to see, to tuck tuck for a taxi cab. So I can't transport my vitamin D to the actual receptors, not very well. Your vitamin D binding proteins binding capacity, and what is vitamin D binding protein bind to vitamin D. And so your vitamin D binding protein, it's affinity, it's taxi cab, passenger pickup capacity is very, very low. In fact, you have the lowest vitamin D binding capacity.

Speaker 4: (32:38)
Then when your vitamin D, which of course, you've just gotten these to see the tactics driving around, taking the vitamin D as opposed to a nice group of them and dropping them off. Once they get to your receptor, remember that the vitamin D isn't going to enter yourself through, you know, endocytosis or just by diffusion. It has to enter the cell through this lock and key receptor model. Do you want vitamin D to be so controlled? Because as much as we love it, once vitamin D enters the cell, it's going to cause some profound gene expression changes, one, something that can do that to your gene expression, to just be getting in and out of the cell Willy nilly. So it has to go through the receptor. Well, then we hit another snafu with Lisa. You see, Lisa has a low affinity receptor.

Speaker 2: (33:36)
Oh, so I got double whammy.

Speaker 4: (33:39)
So yes, Lisa has the ability to activate and make her vitamin D catalytically efficiently, but frankly thereafter, she's not transporting it very efficiently, nor is she absorbing it into the cells very efficiently, relatively speaking, obviously, vitamin D will do you no good floating around your bloodstream in order for vitamin D to do what it needs to do. It's got to get into yourself and hence tying it back to the current exposure that we're dealing as a humanity as a race with, you know, this new virus that has showed up on the scene. And we will have many more of these to deal with in the generations and years to come with. If we are to fight at that first primordial level with our antimicrobial peptides, these genes that need to be turned on. And the thing that is turning on these genes is vitamin D, but in order to do so, the vitamin D has to get into your cell and get into your nucleus. You can understand here audience and Lisa, if you just did a superficial report and said, Oh, look, you're CYP2R1 is efficient, least happy. She makes vitamin D very efficiently without that holistic understanding of really what's going on, we would have missed a hugely important perspective that this actually is at risk for not a transporting be absorbing the vitamin D, which is really ultimately what you need to have happened. Is that clearly, yes.

Speaker 2: (35:22)
If I, if, if I take a vitamin D supplement, then I'm not, I'm still going to have the same problem.

Speaker 4: (35:29)
Now here comes the biohack and you've just nailed it. You say, and Lisa, have you ever from time to time tested your vitamin D and what do they tend to come back? No, I haven't. I've never done this. This is what to know. And of course it's still on my bucket list. And in fact, Lisa, for me to visit them, then we'll have a chance to come visit Lisa, your awesome, awesome country, for sure. Fair enough. See system now that you know what you know, it will do you no good to be one of those individuals that does this mega dose vitamin D once a week, three weeks. So once I've extended that some people, well, I went to the doctor because what did that megadose do to you or do for you your body in order for vitamin D to be stored in your party, by the way, it has to at least, and what you're taking is three, which still needs to go to the liver, which still needs to be activated, which then needs to leave the liver.

Speaker 4: (36:41)
And at least in when the vitamin D gets to other post cells, the fatty cells, then when those cells absorb the vitamin D they can be stabilized, hence the term vitamin D being fat soluble. But now that we know Lisa has what she has in order to play to the better tune of Lisa's body are each a plea to the tuna from genetics. What is far more advisable for Lisa? Far more advisable is let's just assume, let's just assume that we can tell someone you should take 5,000, our use of vitamin D daily and the average person says, okay. And so they take 5,000 for a thing in the morning, or whenever they do with Lisa, what you need to do is you need to take your vitamin D on a much more secure median dosing regimen that you take in the morning a little bit at lunchtime, a little bit in an early afternoon, so that you are playing to the limited capacity that you'll find transport and absorb this change in benefit that your body is designed based on your noble, beautiful heritage and ethnicity, you are better designed to be the person who is getting a more consistent daily exposure of sun.

Speaker 4: (38:02)
When you get morning sun, your mid day sun, your afternoon sun.

Speaker 4: (38:09)
So I've been having mine all in the morning, and then they won't be doing cutting the mustard. So to speak only beneficial, benefiting from a fraction of what you're taking to the truth that should benefit them. We see this, we measure hundreds and hundreds of patients that fall into the category that you fall into. Certainly they need to take it. And certainly you're taking what you've been taking in the morning is better than not. However, these individuals still often struggle to optimize as well as simply how they're feeling and not until we give them the same dose. And here's the point we give them the same daily dose. Will we simply parcel it out from morning, lunchtime afternoon, dosing regimen and their level to become better. They feel better. The type of things we're looking for is better in those individuals from a physiology perspective.

Speaker 4: (39:06)
So this Lisa is exactly in its beautiful little nuance, the full story of functional medicine, functional genomics, functional genomics, understanding that it was not just a single gene. It was the system. And understanding that when we enable optimal cellular uptake of vitamin D, we're not just feeding the cell a trivial micronutrient, we're feeding the cell something that will have profound ramifications on gene expression, things such as boosting antimicrobial peptide production, which is why they've always been provocative, not just an adult or pockets of studies that do emphasize that optimizing vitamin D at times of infections is exceedingly important for healthy outcome. Then you always get that story. And this is the point that if we just ended here, we would have done hopefully a service to your community. You get those studies that go seconds that study could not duplicate the G the shortening, the duration of the viral infection or reducing the severity of the symptoms with vitamin D dosing study did not do the study may have studied a hundred people giving them vitamin D and maybe, you know, the consistency of the outcome wasn't there, but they did not ask the person like Lisa and the study.

Speaker 4: (40:42)
They would have given that person a thousand are using the morning a hundred people and expect that somehow magically, if I give a thousand a hundred people, a thousand, I'll use the vitamin D in the morning. They're somehow going to benefit from the thousands are use equally all in the hundred. We designed clinical studies. And so we've got a poorly designed study that did not understand the individuality with which that person was going to benefit from the vitamin D. And then we make this audacious claim C vitamin D dosing does not do anything. There's no evidence to suggest that vitamin D helps with the common flu or anything else. And there's enough why it's important. Forget your dreams, nothing just vitamin D week Ultimately, that's it.

Speaker 2: (41:38)
Wow. So that is mind blowing. So now I know what to do. I mean, I've been taking my vitamin D uh, 2000 I use in the morning, but now I probably need to take probably 5,000 over the course of the day, but not too late at night, because you don't want to have it at night.

Speaker 4: (41:55)
No, you understand if vitamin D enters yourselves churns on terms of genes, guess what? Some of the genes that it's turning on, their circadian rhythm genes, which in a normal setting we're making naturally by being in the sun, hasn't been designed as one of the gene transcribing signals that helps the body to understand when is it daylight? When is it night time? So if we took the same 5,000 here, three different dosing schedules, 5,000 are used in the morning or versus 5,000. I use 9:00 PM at night, or versus a couple thousand in the morning, a couple of thousand at lunchtime, and maybe a final thousand at three to 4:00 PM. Nothing later than that, the impact on the body can be Fastly drift. First to begin to based on your individual journey, secondly, taking 5,000 in the evening to whatever extent you did absorb, you just told your body at 9:00 PM, wake up it's morning.

Speaker 2: (43:09)
It is mind blowing. That is really fascinating. Don't take your vitamin D late at night, if you want to sleep, because you just talk to your body. It's the morning. Cause that's when the sunshine comes out and we are, you know, ancient beings that have mucked up our circadian rhythms by being in indoors and light and so on, but that's topic for another day. Okay? So there's the story of vitamin B and vitamin D. In my case, I've got a poor chain then it's cause when there's lots of other ones that I wanted to,

Speaker 4: (43:41)
So now let's shift gears here. But the reason I started with biting the ages as an FYI, because of the, because of COVID COVID, but what was another finding reset with the COVID and what was, what started to open the eyes to the clinical community? That COVID was, was a beast of a tad different color. When it came to viral infections, are you in a chain to corona virus, super contagious, the profound vascular rule, the comorbidities of vasculature physiologists. We early on, we recognized hold on. As with many other viruses, the impact of these viruses clearly was not the same. You know, you've got a virus, everyone that gets a particular virus, a gets ill, certain physiologies, and then they go through the course of the illness. And then there are different degrees of outcome with this coronavirus, as many other coronaviruses, there was a clearly wide spectrum of physiologic outcomes and cost of diseases from obviously every fall that is exceedingly mild.

Speaker 4: (44:55)
So that they're, you know, individuals who go, Oh, this is not very serious too. That is definitely well, one of the comorbidities that was helping us for yardage that community is individuals that have certain risks of preexisting vascular health concerns. Well, it turns out that one of the important core factors here is the sensitivity and the health of the, what is called the glycocalyx of the blood vessels. What is the glycocalyx of the blood vessels? Think of your glycocalyx as the Teflon coating on the inner lining of your blood vessels. You see every living break, we, every living, breathing, waking, sleeping moments of life, blood is swishing past the inner lining of our blood vessels. Number one. So there is share stress on the inner lining of our blood vessels, if you took, and we all know these things experiments, if you took the hardest marble or concrete or grenades, and you just took a drop of water and it just drip, drip, drip, over time, it can have quite the wear and tear on a split.

Speaker 4: (46:15)
Likewise, and that's a D at an even accelerated level. If you've got some liquid swishing past, this is called the sheer sheer force so that our blood, depending on other parameters of blood pressure and so on and so forth, it's swishing past the inner lining of our blood vessels and the health and the resilience of the inner lining of the blood vessel is extremely important in dictating longitudinal vascular health. Well, one of the key components and findings of the coronavirus, this particular one, the solid school retune is what it's, the places that can infect are one of the places where there are these two receptors is the lining of the blood vessels. Now, why did we stop with vitamin D? Not just because it's this awesome story, but because vitamin D other than its role in playing, turning on these antimicrobial peptides, vitamin D also plays this massively important role in controlling and toenail.

Speaker 4: (47:32)
The inflammatory response and cells see inflammation, which is, seems like this overly generic term, but it's not. Inflammation is one of the most awesome examples of a cascade inflammation is an example of an avalanche that once it gets going, we either trunk, we need it for certain responses, but we want to truncate it early on inflammation and the factors that lead to and continue inflammation to stay overly long, because then we enter into chronic inflammation, vitamin D in its role in turning off and turning on genes plays a radically important job in controlling and limiting chronic inflammation.

Speaker 4: (48:27)
Chronic inflammation becomes one of the key downstream consequences when we have too much share stress and inflammation at the lining of the blood vessel, viral infections, such as the salts Colby to virus, what does it cause? What it enters the cell inflammation. If there are things like hypertension, type two diabetes and so on and so forth, preexisting and a person, what do we have? We have preexisting conditions of vascular endothelial inflammation. If you add on top of that preexisting vascular inflammation through hypertension, through type two diabetes. Now you add to that a viral infection that is going to accelerate. Add to that inflammation. Now you can start to see why individuals with premorbidities of type two diabetes. Uh, hypertension are the ones who have an increased risk of more severe.

Speaker 4: (49:44)
So now what we've just done is we've looked again, functional, good physiology, understanding the contributing components. Now let's look at the genetics you see at the seat of whether there's going to be inflammation of the lining of the, or the risk of it is the quantity of your Teflon coating. So we all have this thing, this Teflon coating that shields, that covers it's called the glycocalyx the lining of the blood vessels. Okay? Now we all know, you know, here, Lisa, I'm not showing New Zealand, there's this amazing store where if you ever wanted to, you know, if you're, if you're a foodie in a kitchen of aficionados, it's called the Williams Sonoma store. So that's where you get awesome gadgetry. That's where you get the good quality stuff in America. We'll say, if you go to Teflon coated frying pan from Williams, Sonoma, you would have gotten this really good quality Teflon coated frying pan.

Speaker 4: (50:52)
I'm not advocating Teflon, Teflon coated fine, teflon golden from the dollar store. Now I've got this dollar store Teflon coated frying pan. This Williams Sonoma Teflon coated fire, but they're both Teflon coated, but anyone who knows these two stores knows that a month into using the dollar store frying pan, the Teflon has worn off. It starts sticking and burning. The food continues to be nonstick well, a person's genetic makeup dictates or contributes significantly to their glide glyco, Calexico health. I E genetically contributes. Do you have innately the really good quality Teflon coating or the weaker Teflon coating now to your point to the very start yearly. So if you genetically had the week a Teflon coaching, do you throw your hands up and go, well, I've got the week Teflon coating. Can't do anything about it. I'm going to kick the bucket from a stroke or from a heart from heart disease.

Speaker 4: (52:06)
There's no cousin bought you the dollar store find pine for Christmas. And he still insists coming over to make sure you're using that gift that he gave you. How are you going to do? You're going to use the chief of quality tougher quoted fine, fine, but you're going to take some preventative measures. You're not going to use a very harsh scrubbing brush. You probably going to make sure you use a good non, you know, a good oil. The good cooking oil is the case. You'll do certain things, knowing that the quality isn't the best. So there are three genetic markers that contributes to a person's Teflon, coating quality, three independent markers. These markers are all existing. They all occur in a very special part of your human genome known as the chromosome nine P two, one region. It's an actual chapter in your human operating manual. And in that chapter are some of the most important vascular related genes of which these nine P two, one genetic markers of foul the nine pitcher when genetic markers are so important to vascular health, when they were discovered, this part of the human genome was called the heart of the human genome, because it's so important to many of them.

Speaker 4: (53:42)
three 9P21 markers. We all have each of these three 9P21 markers. We have two copies, one from mom, one from dad, and they've got three of these. So I've got six 9P21 markers that I'm going to look at six of them. Each of these six marks comes as either an a as an alpha version G as in George version. So in other words, one human being my time, all six days, zero genes, another person five days, one G full is two GS, three days, three, and so on and so forth until you have another human being who has no, A's all genes. What this means is we have what is called a six G spectrum. The more, the number of GS a person has the weaker. The weaker is that glycocalyx, this is the residual that inherited the dollar store, Teflon coated, fine pan. This is the individual that has to be more mindful about how they're going to treat the surface of their blood vessel. They show that their blood pressure is being moderated appropriately. They've got to ensure that there aren't too many inflammatory things in the bloodstream that would act as a bridge to the surface. They've got to ensure that they're optimal ensure that there's controlling inflammation and so on and so forth. Lisa, 6 genes

Speaker 2: (55:21)
Oh my gosh. So this is, this is, you know, when I got this report back, I was like, Oh no, that's not a good thing, but instead of being negative about it, what can I do about it? So I can take vitamin D what else can I do?

Speaker 4: (55:34)
Well, first do what you need to do to reduce that sheer stress being six gene and suffering from hypertension is not a good combination. So having the 6 genes, having a surface, having a glycocalyx that is weaker. Okay. Fair enough. Okay. The last thing you want is to have that weakest surface and be constantly abrasive. That's the last thing you want. So let's start from the top. Once we know that a person's a six G that person, and of course, Lisa has championed healthy lifestyle living Lisa's fitness level. I would imagine that your heart rate and your blood pressure as the last through purposeful serendipitous, but purposeful lifestyle, ambitions and pursuit you have just gone from, okay, I've got the six gene you've pulled the rug out from that being a concern for you most entirely as yet, but significantly by ensuring that your blood pressure, your heart rate blood pressure is as good as it can possibly get.

Speaker 4: (56:48)
Step step, number two, the things in the bloodstream of the things that were there to get into the blood, they would be like, that would really be inflammatory to the lining of the blood vessel. Well, that's where we get those like toxins, isn't it. Right? But all of those food preservatives, heavy metals, simply toxins, including by the way, many, many, many medications pharmaceutics. We all know. I mean, what's the first thing. When a person is puts on a Staton and the person's put on a seven, and by the way, this is not about anti-static. I'm just stating a fact, when a doctor puts a person a status that doctor has to follow up with the liver health of that person, because we know that over time, by giving a person a Staton, we are giving the liver extra, extra work to deed the medication and question and polluting acetaminophen, Tylenol, you name it, these medications, which are absolutely appropriate when appropriate, but there are examples of things that when they get into the bloodstream, they are abrasive to the lining of the blood vessels.

Speaker 4: (

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